Complement Membrane Attack Complex
نویسندگان
چکیده
منابع مشابه
Structural basis of complement membrane attack complex formation
In response to complement activation, the membrane attack complex (MAC) assembles from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a 'multi-hit' mechanism; however, sublytic MAC pores on host cells activate signalling pathways. Previous studies have described the structures of individual MAC components and subcomplexes; however, the molecular details of...
متن کاملGeneration of complement membrane attack complex in normal human corneas.
PURPOSE To determine whether complement-derived SC5b-9, the soluble nonlytic-fluid phase of the membrane attack complex, can be generated in normal human corneas when they are injured with lipopolysaccharide (LPS), ribitol teichoic acid (RTA) immune complexes, acid, or alkali. METHODS The experimental cornea of each donor pair was injected with 50 microliters of sterile saline containing 0.5 ...
متن کاملNeoantigens of the membrane attack complex of human complement.
The membrane attack complex of complement is a fusion product of five complement proteins: C5b, C6, C7, C8, and C9. The complex causes complement-dependent cell membrane damage. It is assembled following complement activation both on the target cell surface and in the fluid phase. The isolated soluble complex, which has a molecular weight of one million, exhibited reduced expression of the anti...
متن کاملComplement membrane attack and tumourigenesis
Tumour development driven by inflammation is now an established phenomenon but the role that complement plays remains uncertain. Recent evidence has suggested that various components of the complement (C) cascade may influence tumour development in disparate ways; however, little attention has been paid to that of the membrane attack complex (MAC). This is despite abundant evidence documenting ...
متن کاملComplement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex.
Complement is a central effector system within the immune system and is implicated in a range of inflammatory disorders. CD59 is a key regulator of complement membrane attack complex (MAC) assembly. The atherogenic role of terminal complement has long been suspected but is still unclear. Here, we demonstrate that among mice deficient in apolipoprotein (Apo)E, the additional loss of murine CD59 ...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2020
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2020.02.006